↑

Delicious Little Bites

Loving Life One Bite at a Time

  • About
    • Disclosure Statement
    • Work With Me
    • Contact Me
  • Recipe Index
  • Low Carb
  • Gluten Free
  • Vegetarian
  • Desserts
  • Privacy Policy
You are here: Home / Recipes / Main Dish / Chicken / Creamy Buffalo Chicken Spaghetti Squash Casserole

Creamy Buffalo Chicken Spaghetti Squash Casserole

Published January 19, 2023 by Lauren Vavala

Thanks for sharing!

A spoon lifting up some buffalo chicken spaghetti squash casserole in the baking dish with text overlay.
Close up of buffalo chicken spaghetti squash casserole with text overlay.
A spoonful of buffalo chicken spaghetti squash casserole with text overlay.
A spoon lifting up some buffalo chicken spaghetti squash casserole in the baking dish with text overlay.

Creamy Buffalo Chicken Spaghetti Squash Casserole is cheesy, spicy, and incredibly delicious! Made with only 5 ingredients, it’s low in carbs and suitable for those following a keto, low carb, or gluten free diet.

Close up of a wood spoon lifting up some buffalo chicken spaghetti squash casserole in a white baking dish.

This post contains affiliate links. See our Disclosure Statement for more information.

Buffalo chicken recipes have been incredibly popular the last several years. What started out as a delicious party dip has evolved into many different main dish options. 

My recipe for Creamy Buffalo Chicken Cauliflower Casserole is one of the most popular recipes on this website. I don’t know why it took me so long to try it with spaghetti squash, but here we are, finally!

This Creamy Buffalo Chicken Spaghetti Squash Casserole has all of the same cheesy, spicy flavor, but with a much milder base. The flavor of the spaghetti squash is not as strong as cauliflower so it’s a better option for those who don’t care for cauliflower or simply enjoy spaghetti squash.

Why This Recipe Works

  • 5 ingredients is all it takes to make this super flavorful casserole dish! Of course you can always add celery, onion or bell peppers to the mix, if you like.
  • Cream cheese is blended with a sharp cheddar cheese for a smooth, creamy base.
  • Classic Buffalo sauce brings plenty flavor and spiciness.
  • Spaghetti squash is not only a healthy base for this recipe, but, with only 6 net carbohydrates per serving, it is much lower in carbohydrates than traditional pasta. Chunks of chicken add plenty of protein making this casserole suitable for those on low carb or keto diets.
  • This recipe is naturally gluten free.

Step-By-Step Instructions

Ingredients

Ingredients needed to make creamy buffalo chicken spaghetti squash casserole on a marble background with text overlay.

  • 1 1/2 pounds cooked chicken (diced or shredded)
  • 1 medium spaghetti squash (about 5 cups cooked)
  • 8 ounces cream cheese
  • 1/2 cup buffalo sauce
  • 8 ounce sharp cheddar cheese (shredded)

The entire recipe and instructions can also be found in the recipe card at the bottom of this post. You can also print the recipe from the card, if needed.

Prep!

Dice and cook your chicken, or shred it, if preferred.

Chef’s Tip: Leftover or rotisserie chicken works great for this recipe. I also like to use my Instant Pot to cook the chicken which makes it super easy to dice and shred.

Shred the cheddar cheese.

Chef’s Tip: It is not recommended to use a bagged shredded cheese as it contains a starch to keep it from sticking together. That starch makes it so that the cheese doesn’t melt as nicely and may increase the total carb count.

Preheat your oven to 375°F.

Create!

Cook the spaghetti squash first so that it has time to cool. You can either microwave or roast it. For this recipe, I prefer to microwave it since the buffalo sauce is the dominate flavor and the flavor of the spaghetti squash doesn’t come through much at all.

Spaghetti squash cut in half with strands scraped out still inside of the skin.

To microwave the spaghetti squash, leave it whole and pierce about 10 holes into it.

Microwave on high for 8-10 minutes or until tender. Allow it to cool before cutting it in half and removing the seeds.

Then, use a fork to scrape out the inside into spaghetti-like strands.

Chef’s Tip: for detailed instructions on how to roast spaghetti squash, please see this recipe for Tuscan Spaghetti Squash.

Cream cheese buffalo sauce in a black skillet.

Meanwhile, prepare the sauce by adding the cream cheese to a large, deep skillet over medium heat. Add the buffalo sauce and continue to melt and blend. 

Once the cream cheese is mostly melted, turn off the heat and stir in half of the cheddar cheese. It may not be perfectly smooth yet, but will melt more later.

Spaghetti squash and chicken mixed into a cheesy buffalo sauce in a black skillet.

Stir in the hot spaghetti squash and cooked chicken. Mix well. By now the sauce should be smooth and creamy.

Buffalo chicken and spaghetti squash in a white, square casserole dish.

Spread into a medium casserole dish.

A casserole topped with shredded cheddar cheese in a white, square baking dish.

Top with the remaining cheddar cheese.

A baked buffalo chicken spaghetti squash casserole in a white, square casserole dish.

Cover loosely with foil and bake for 20-25 minutes.

Remove the foil and bake for an additional 10 minutes or until the cheese is melted and bubbling.

Present!

Close up of a creamy buffalo chicken spaghetti squash casserole topped with buffalo sauce and parsley in a white baking dish.

Top the baked casserole is with extra buffalo sauce or Ranch dressing and fresh, minced parsley, if desired.

Tips and Techniques

  • Cut the chicken into bite size cubes and cook in a skillet with olive oil until just done through, or use an Instant Pot, or use leftover or rotisserie chicken to save time.
  • It is best to shred the sharp cheddar cheese from a block rather than buying a bag of pre-shredded cheese which contains a starch and doesn’t melt as well.
  • For detailed instructions on how to roast spaghetti squash, please see this recipe for Tuscan Spaghetti Squash.
  • Store any leftover casserole in an airtight container in the refrigerator. Consume within 3-4 days.

FAQ’s

Can You Store Buffalo Chicken Casserole In The Freezer?

Yes, a buffalo chicken casserole can be stored in the freezer tightly covered and unbaked, for up to 6 months. Thaw in the refrigerator before baking. Increase the cook time to 35 minutes covered, then 10 minutes uncovered.

Can Buffalo Chicken Casserole Be Made Ahead Of Time?

This casserole can be made ahead of time and kept in the refrigerator, tightly covered. It is recommended to bake it within 2 days. Increase the cook time to 35 minutes covered, then 10 minutes uncovered.

More Buffalo Chicken Recipes

Buffalo Chicken Lettuce Wraps
Lunch is easy, healthy, and delicious when you make these Buffalo Chicken Lettuce Wraps. With only 5 net carbs per serving, they are low carb, keto friendly, and gluten free.
Get The Recipe
Close up of a Buffalo Chicken Lettuce Wrap on a white plate with more wraps blurred in the background with a cutting board, cucumber slices, blue cheese, and a blue and white towel.
Buffalo Chicken Burgers
This easy recipe for Buffalo Chicken Burgers is super versatile and a healthy alternative to traditional hamburgers. These flavorful, spicy patties are low carb, keto friendly, and gluten free. The simplicity in preparing this delicious entree will have you craving another zesty Buffalo Chicken slider soon.
Get The Recipe
A hand holding a buffalo chicken burger
Buffalo Chicken Meatballs
Buffalo Chicken Meatballs are easy to make, spicy, and delicious! They are a lightened up version of Buffalo chicken wings and less messy to eat.
Get The Recipe

Love this Buffalo Chicken Spaghetti Squash Casserole recipe? Follow me on Pinterest, Instagram, and Facebook for more!

If you try this recipe, I would really appreciate it if you would please leave a comment and star rating. Thanks!

Close up of a wood spoon lifting up some buffalo chicken spaghetti squash casserole in a white baking dish.
Print

Creamy Buffalo Chicken Spaghetti Squash Casserole

Creamy Buffalo Chicken Spaghetti Squash Casserole is cheesy, spicy, and incredibly delicious! Made with only 5 ingredients, it’s low in carbs and suitable for those following a keto, low carb, or gluten free diet.
Course Main Dish
Cuisine American, Chicken
Prep Time 20 minutes
Cook Time 35 minutes
Total Time 55 minutes
Servings 6 servings
Calories 494kcal
Author Lauren Harris

Ingredients

  • 1 medium spaghetti squash (about 5 cups cooked)
  • 8 ounces cream cheese
  • 1/2 cup buffalo sauce
  • 8 ounce sharp cheddar cheese (shredded, divided)
  • 1 1/2 pounds cooked chicken (diced or shredded)

Instructions

  • Preheat oven to 375°F.
  • To microwave the spaghetti squash, leave it whole and pierce about 10 holes into it. Microwave on high for 8-10 minutes or until tender.
    1 medium spaghetti squash
  • Allow it to cool before cutting it in half and removing the seeds. Then, use a fork to scrape out the inside into spaghetti-like strands.
  • Meanwhile, prepare the sauce by adding the cream cheese to a large, deep skillet over medium heat. Add the buffalo sauce and continue to melt and blend. 
    8 ounces cream cheese, 1/2 cup buffalo sauce
  • Once the cream cheese is mostly melted, turn off the heat and stir in half of the cheddar cheese. It may not be perfectly smooth yet, but will melt more later.
    8 ounce sharp cheddar cheese
  • Stir in the hot spaghetti squash and cooked chicken. Mix well. By now the sauce should be smooth and creamy.
    1 1/2 pounds cooked chicken
  • Spread into a medium casserole dish.
  • Top with the remaining cheddar cheese.
  • Cover loosely with foil and bake for 20-25 minutes.
  • Remove the foil and bake for an additional 10 minutes or until the cheese is melted and bubbling.
  • Top with extra buffalo sauce or Ranch dressing and fresh, minced parsley, if desired.

Notes

Tips and Techniques

  • Cut the chicken into bite size cubes and cook in a skillet with olive oil until just done through, or use an Instant Pot, or use leftover or rotisserie chicken to save time.
  • It is best to shred the sharp cheddar cheese from a block rather than buying a bag of pre-shredded cheese which contains a starch and doesn’t melt as well.
  • For detailed instructions on how to roast spaghetti squash, please see this recipe for Tuscan Spaghetti Squash.
  • Store any leftover casserole in an airtight container in the refrigerator. Consume within 3-4 days.
** Nutritional information is an estimate and may vary.

Nutrition

Serving: 1serving | Calories: 494kcal | Carbohydrates: 7g | Protein: 40g | Fat: 34g | Saturated Fat: 17g | Polyunsaturated Fat: 3g | Monounsaturated Fat: 9g | Cholesterol: 161mg | Sodium: 1074mg | Potassium: 403mg | Fiber: 1g | Sugar: 3g | Vitamin A: 1005IU | Vitamin C: 1mg | Calcium: 331mg | Iron: 2mg

Related Posts

A wood turner lifting up a piece of chicken in a chicken parmesan casserole.
Spaghetti Squash Chicken Parmesan (Parmigiana)
A jalapeno popper chicken casserole with a wood server lifting some up.
Low Carb Jalapeño Popper Chicken Casserole
A wood turner lifting up a serving of ranch bacon chicken casserole.
Ranch Bacon Chicken Casserole
Close up of Greek chicken breasts.
Braised Greek Style Chicken Breasts
Skillet Creamy Lemon Chicken with Cauliflower in a Skillet Topped with Fresh Thyme
Skillet Creamy Lemon Chicken with Cauliflower

Filed Under: Chicken, Gluten Free, Low Carb, Main Dish, Recipes

Welcome, I'm Lauren!

Delicious Little Bites is where I share all types of recipes from appetizers to desserts. You will also find plenty of keto, gluten free, and vegetarian recipes here to help you put a delicious meal on the table every night that the whole family will love! Read More...

as seen on


Copyright ©2023, Delicious Little Bites. All Rights Reserved.